advancing scientific discovery with evidence-based research

The aim of the Beckley Foundation Scientific Programme is to increase understanding of brain function and consciousness. We use psychoactive substances as tools to alter brain activity. By investigating these changes with the latest brain-imaging technology, we open up exciting new avenues of treatment for physical and mental conditions, and unveil the mechanisms by which psychedelics produce their profound effect. By changing consciousness, we learn more about normal consciousness.

To date, the Beckley Foundation has conducted scientific studies in conjunction with some of the world’s leading academic institutions, including Johns Hopkins, Imperial College, University College London, and King’s College. A summary of the Beckley Foundation Scientific Research Programme is available online by clicking here.

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

October 15, 2012 BF Scientific Publications

A new analysis of the original psilocybin fMRI data has recently been published in a new paper in Schizophrenia Bulletin, in which the psychedelic state is analysed for similarity with early psychosis, as both share similar effects on how different areas of the brain communicate with eachother.

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Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

October 11, 2012 BF Scientific Publications

Amanda Feilding is one of 14 authors on a new study which supports the idea that high-THC/low-CBD cannabis products are associated with increased risks for mental health. Click the link to download the full PDF from the Journal of Psychopharmacology Click here to download the original article and access the FULL PDF document In this […]

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MDMA for treating post traumatic stress disorder: 80% success rate. Beckley Foundation’s work on psilocybin also praised

July 8, 2011 Beckley Science in the Media

An article posted by Craig K. Comstock on the Huffington Post talks of the huge success of Michael Mithoefer’s study into the medicinal purposes of MDMA, in particular reference to treating post traumatic stress disorder (PTSD). After MDMA-assisted psychotherapy, 80% no longer met the diagnostic criteria for PTSD, as compared to only 25% in the […]

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Slow-Wave Oscillations in the Craniosacral Space: A Hemoliquorodynamic Concept of Origination

November 9, 2010 Beckley Science in the Media

The mechanism of formation of rhythmic, slow-wave oscillations in the craniospinal cavity were studied. Synchronous bioimpedance traces were made of the head and lumbosacral part of the spine in five healthy young subjects at rest and during voluntary breath-holding; these reflect changes in the ratios of blood and CSF volumes in these parts of the […]

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Does intravenous 9-tetrahydrocannabinol increase dopamine release? A SPET study

November 5, 2010 Beckley Science in the Media

ABSTRACT Intravenous (IV) _9-tetrahydrocannabinol (THC) induces transient psychotic symptoms in healthy subjects and in schizophrenic patients, but the psychotomimetic mechanism is unknown. One possibility is that THC stimulates dopamine (DA) release in the striatum. In this study we tested whether IV THC led to an increase in striatal DA release compared to placebo. We also […]

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Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology

November 5, 2010 Beckley Science in the Media

ABSTRACT: In healthy individuals, D-9-tetrahydrocannabinol (D-9- THC), the main psychoactive ingredient of the Cannabis sativa plant, can induce psychotic symptoms and anxiety, and can impair memory (D’Souza et al, 2004) and psychomotor control (McDonald et al, 2003; Ramaekers et al, 2006). In patients with schizophrenia, D-9-THC may exacerbate existing psychotic symptoms, anxiety and memory impairments […]

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Plasticity Changes in the Brain in Hypnosis and Meditation

November 4, 2010 Beckley Science in the Media

PLASTICITY CHANGES IN THE BRAIN IN HYPNOSIS AND MEDITATION FULL DOC: http://archive.beckleyfoundation.org/bib/doc/bf/2009_Ulrike_211569_1.pdf Abstract Neuroscientific evidence interprets both hypnotic trance induction and different meditation traditions as modified states of consciousness that emphasize attention, concentration and the letting go of thoughts, but they differ in terms of sensory input, processing, memory, and the sense of time. Furthermore, […]

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