A9-THC) in laboratory animals, the present work was carried out to study possible interaction between CBD and A9-THC in human beings. In a double blind procedure, 40 healthy male volunteers were assigned to 1 of 8 experimental groups, receiving per oral route, placebo, 30 mg A9-THC, 15, 30 or 60 mg of CBD, and mixtures of 30 mg of Ag-THC plus either 15, 30 or 60 mg of CBD respectively. Pulse rate, time production tasks and psychological reactions were measured at several time intervals after drug ingestion. 30 mg ~9-THC alone increased pulse rate, disturbed time tasks and induced strong psychological reactions in the subjects. 15-60 mg of CBD alone provoked no effects. On the other hand, CBD was efficient in blocking most of the effects of Ag-THC when both drugs were given together. CBD also decreased the anxiety component of Ag-THC effects, in such a way that the subjects reported more pleasurable effects.
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